The IVNS1ABP Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The IVNS1ABP Antibody has been validated for the following applications: Western Blot.
Description
Description: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).
Subunit Structure: Homodimer; through the BTB domain (By similarity). Interacts with AHR/Aryl hydrocarbon receptor (PubMed:16582008). Interacts with HNRNPK (PubMed:23825951). Interacts (via kelch repeats) with KLHL20 (via kelch repeats); this interaction blocks the assembly of Cul3-KLHL20 complex (PubMed:25619834).
Similarity: When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP